Maxwell M. WintrobeSherrie L. PerkinsFrixos Paraskevas and John FoersterFrixos ParaskevasFrixos ParaskevasMaria R. BaerRebecca L. Shattuck-Brandt and Stephen J. BrandtMaurice C. Bondurant and Mark J. KouryEmmanuel N. DessyprisMarilyn J. Telen and Russel E. KaufmanG. Richard Lee and Victor D. HerbertAndrew DeissKeith M. SkubitzRedwan Moqbel and Allan B. BeckerA. Dean Befus and Judah A. DenburgJ. Brice WeinbergFrixos ParaskevasFrixos Paraskevas and John FoersterFrixos ParaskevasFrixos ParaskevasFrixos ParaskevasPaula E. Stenberg and Ronald J. HillLeslie V. Parise and Christel Boudignon-Proudhon and Patricia J. Keely and Ulhas P. NaikCharles S. Greenberg and Carolyn L. OrthnerGeorge M. RodgersMarlis L. SchroederMarlis L. SchroederRichard A. NashG. Richard LeeG. Richard LeeG. Richard LeeG. Richard LeeG. Richard LeeG. Richard LeeRobert T. Means, JrSylvia S. BottomleyJohn N. LukensCorwin Q. EdwardsSylvia S. Bottomley and G. Richard LeeG. Richard LeeBertil E. Glader and John N. LukensBertil E. Glader and John N. LukensBertil E. Glader and John N. LukensCharles J. Parker and John FoersterJohn M. BowmanAnne T. ThomasCharles J. Parker and G. Richard LeeG. Richard LeeJohn FoersterJohn N. LukensWinfred C. Wang and John N. LukensJohn N. Lukens and G. Richard LeeJohn N. LukensDarryl M. WilliamsG. Richard LeeG. Richard LeeG. Richard LeeJeffrey D. Hord and John N. LukensRobert T. Means, JrGeorge M. Rodgers and Thomas C. BithellShirley Parker LevineShirley Parker LevineShirley Parker LevineShirley Parker LevineMatthew M. Rees and George M. RodgersShirley Parker LevineShirley Parker LevineGeorge M. Rodgers and Charles S. GreenbergAlan B. M. Grosset and George M. RodgersGeorge M. RodgersThomas L. McCurley and John P. GreerJames C. Gay and John W. AthensRaymond G. WattsKeith M. SkubitzMargaret M. McGovern and Robert J. DesnickH. Stacy Nicholson and John N. LukensJohn FoersterRobert L. JancoWilliam C. Chapman and Martin NewmanJohn B. Cousar and Charles L. Sawyers and Stephan W. Morris and Martin U. KueferEdward R. Arrowsmith and John P. Greer and William R. MaconKenneth R. HandeAsha KallianpurStanford J. StewartJohn F. Tisdale and Cynthia E. Dunbar and Stacey A. GoodmanMarsha C. Kinney and John N. LukensJames A. Whitlock and Paul S. GaynonJohn P. Greer and Maria R. Baer and Marsha C. KinneyAlan F. List and Donald C. DollRichard S. Larson and Steven N. WolffRobert T. Means, JrDouglas A. Clark and Wilbur L. WilliamsJames B. JohnstonJames B. JohnstonJohn P. Greer and William R. Macon and Thomas L. McCurleyRichard S. SteinJohn A. Zic and Kevin E. Salhany and John P. Greer and Lloyd E. King, Jr.John FoersterJohn Foerster and Frixos ParaskevasJohn FoersterJohn FoersterJohn FoersterJohn FoersterSherrie L. PerkinsHarvey A. Ragan

Preface	p. vii
Contributors	p. ix
Part I. Introduction
1. The Diagnostic and Therapeutic Approach to Hematologic Problems	p. 3
Part II. Laboratory Hematology
2. Examination of the Blood and Bone Marrow	p. 9
3. Immunodiagnosis	p. 36
4. Clinical Flow Cytometry	p. 56
5. Clusters of Differentiation	p. 72
6. Cytogenetics	p. 98
7. Molecular Genetics and Hematology	p. 124
Part III. The Normal Hematologic System
Section 1. Hematopoiesis
8. Origin and Development of Blood Cells	p. 145
Section 2. The Erythrocyte
9. Erythropoiesis	p. 169
10. The Mature Erythrocyte	p. 193
11. Nutritional Factors in the Production and Function of Erythrocytes	p. 228
12. Destruction of Erythrocytes	p. 267
Section 3. Granulocytes and Monocytes
13. Neutrophilic Leukocytes	p. 300
14. The Human Eosinophil	p. 351
15. Basophilic Leukocytes: Mast Cells and Basophils	p. 362
16. Mononuclear Phagocytes	p. 377
17. Phagocytosis	p. 415
Section 4. The Lymphocytes
18. The Lymphatic System	p. 430
19. B Lymphocytes	p. 464
20. T Lymphocytes and NK Cells	p. 497
21. Cell Interactions in the Immune Response	p. 544
Section 5. Hemostasis
22. Platelets and Megakaryocytes	p. 615
23. Platelets in Hemostasis and Thrombosis	p. 661
24. Blood Coagulation and Fibrinolysis	p. 684
25. Endothelium and the Regulation of Hemostasis	p. 765
Section 6. Transfusion and Transplantation
26. Red Cell, Platelet, and White Cell Antigens	p. 774
27. Principles and Practice of Transfusion Medicine	p. 817
28. Hematopoietic Stem Cell Transplantation	p. 875
Part IV. Disorders of Red Cells
Section 1. Anemia: General Considerations
29. Anemia: General Aspects	p. 897
30. Anemia: a Diagnostic Strategy	p. 908
Section 2. Megaloblastic Anemias: Disorders of Impaired DNA Synthesis
31. Pernicious Anemia and Other Causes of Vitamin B12 (Cobalamin) Deficiency	p. 941
32. Folate Deficiency: Causes and Management	p. 965
33. Inherited and Drug-Induced Megaloblastic Anemia	p. 973
Section 3. Disorders of Iron Metabolism and Heme Synthesis
34. Iron Deficiency and Iron-Deficiency Anemia	p. 979
35. The Anemia of Chronic Disorders	p. 1011
36. Sideroblastic Anemias	p. 1022
37. Methemoglobinemia and Other Disorders Accompanied by Cyanosis	p. 1046
38. Hemochromatosis	p. 1056
39. Porphyria	p. 1071
Section 4. Hemolytic Anemia
40. Hemolytic Disorders: General Considerations	p. 1109
41. Hereditary Spherocytosis and Other Anemias Due to Abnormalities of the Red Cell Membrane	p. 1132
42. Hereditary Hemolytic Anemias Associated with Abnormalities of Erythrocyte Glycolysis and Nucleotide Metabolism	p. 1160
43. Glucose-6-Phosphate Dehydrogenase Deficiency and Related Disorders of Hexose Monophosphate Shunt and Glutathione Metabolism	p. 1176
44. Mechanisms of Immune Destruction of Erythrocytes	p. 1191
45. Alloimmune Hemolytic Disease of the Fetus and Newborn	p. 1210
46. Autoimmune Hemolytic Anemias	p. 1233
47. Paroxysmal Nocturnal Hemoglobinuria	p. 1264
48. Acquired Hemolytic Anemias Resulting from Direct Effects of Infectious, Chemical, or Physical Agents	p. 1289
49. Red Cell Fragmentation Syndromes	p. 1305
Section 5. Hereditary Disorders of Hemoglobin Structure and Synthesis
50. The Abnormal Hemoglobins: General Principles	p. 1329
51. Sickle Cell Anemia and Other Sickling Syndromes	p. 1346
52. Unstable Hemoglobin Disease	p. 1398
53. The Thalassemias and Related Disorders: Quantitative Disorders of Hemoglobin Synthesis	p. 1405
Section 6. Other Disorders Associated with Anemia
54. Pancytopenia, Aplastic Anemia, and Pure Red Cell Aplasia	p. 1449
55. Acute Post-Hemorrhagic Anemia	p. 1485
56. Congenital Dyserythropoietic Anemias	p. 1489
57. The Anemias Associated with Renal Disease, Liver Disease, Endocrine Disease, and Pregnancy	p. 1497
58. Anemias Unique to Infants and Young Children	p. 1518
Section 7. Erythrocytosis
59. Polycythemia: Erythrocytosis	p. 1538
Part V. Disorders of Hemostasis and Coagulation
Section 1. Introduction
60. The Diagnostic Approach to the Bleeding Disorders	p. 1557
Section 2. Thrombocytopenia
61. Thrombocytopenia: Pathophysiology and Classification	p. 1579
62. Thrombocytopenia Caused by Immunologic Platelet Destruction	p. 1583
63. Thrombotic Thrombocytopenic Purpura and Other Forms of Nonimmunologic Platelet Destruction	p. 1612
64. Miscellaneous Causes of Thrombocytopenia	p. 1623
Section 3. Other Disorders of Primary Hemostasis
65. Bleeding Disorders Caused by Vascular Abnormalities	p. 1633
66. Thrombocytosis	p. 1648
67. Qualitative Disorders of Platelet Function	p. 1661
Section 4. Coagulation Disorders
68. Inherited Coagulation Disorders	p. 1682
69. Acquired Coagulation Disorders	p. 1733
Section 5. Thrombosis
70. Thrombosis and Antithrombotic Therapy	p. 1781
Part VI. Nonmalignant Disorders of Leukocytes, the Spleen, and/or Immunoglobins
71. Diagnostic Approach to Malignant and Nonmalignant Disorders of the Hematopoietic-Lymphoid System	p. 1821
72. Variations of Leukocytes in Disease	p. 1836
73. Neutropenia	p. 1862
74. Qualitative Disorders of Leukocytes	p. 1889
75. Abnormalities of the Monocyte-Macrophage System--The Lysosomal Storage Diseases	p. 1908
76. Langerhans Cell Histiocytosis	p. 1916
77. Infectious Mononucleosis	p. 1926
78. Hematologic Aspects of Acquired Immunodeficiency Disease	p. 1956
79. Disorders of the Spleen	p. 1969
Part VII. Hematologic Malignancies
Section 1. General Aspects
80. The Hematopoietic-Lymphoid Neoplasms	p. 1993
81. Complications of Hematopoietic Neoplasms	p. 2033
82. Principles and Pharmacology of Chemotherapy	p. 2076
83. Supportive Care in Hematologic Malignancies	p. 2102
84. Immunotherapy	p. 2157
85. Gene Therapy for Hematologic Disorders, HIV Infection, and Cancer	p. 2178
Section 2. The Acute Leukemias
86. Classification and Differentiation of the Acute Leukemias	p. 2209
87. Acute Lymphocytic Leukemia	p. 2241
88. Acute Myelogenous Leukemia	p. 2272
89. The Myelodysplastic Syndromes	p. 2320
Section 3. Myeloproliferative Disorders
90. Chronic Myeloid Leukemia	p. 2342
91. Polycythemia Vera	p. 2374
92. Myelofibrosis	p. 2390
Section 4. Lymphoproliferative Disorders
93. Chronic Lymphocytic Leukemia	p. 2405
94. Hairy Cell Leukemia	p. 2428
95. Non-Hodgkin Lymphomas	p. 2447
96. Hodgkin Disease	p. 2538
97. Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sezary Syndrome	p. 2572
Section 5. Plasma Cell Dyscrasias
98. Plasma Cell Dyscrasias: General Considerations	p. 2612
99. Multiple Myeloma	p. 2631
100. Waldenstrom Macroglobulinemia	p. 2681
101. Heavy Chain Diseases	p. 2693
102. Amyloidosis	p. 2705
103. Cryoglobulins and Cryoglobulinemia	p. 2725
Appendices
Appendix A. Normal Blood and Bone Marrow Values in Humans	p. 2738
Appendix B. Comparative Hematology	p. 2749
Index	p. i