Human genetics : problems and approaches

Başlık:

Yazar:

Vogel, Friedrich, 1925-

ISBN:

9783540602903

Ek Yazar:

Vogel, Friedrich, 1925-

Edition:

3rd completely rev. ed.

Yayım Bilgisi:

Berlin ; New York : Springer, c1997.

Fiziksel Tanım:

xxxvi, 851 p. : ill. ; 28 cm.

Contents:

History of human genetics -- The human genome: chromosomes -- The human genome: genes and DNA -- Formal genetics of humans: modes of inheritance -- Formal genetics of humans: linkage analysis and gene clusters -- Formal genetics of humans: multifactorial inheritance and common diseases -- Gene action: genetic diseases -- Gene action: developmental genetics -- Mutation: spontaneous mutation in germ cells -- Mutation: somatic mutation, cancer, and aging -- Mutation: induction by ionizing radiation and chemicals -- Population genetics: description and dynamics -- Population genetics: consanguinity, genetic drift -- Human evolution -- Behavioral genetics: research strategies and examples -- Behavioral genetics: affective disorders and schizophrenia -- Behavioral genetics: differences between populations -- Genetic counseling and prenatal diagnosis -- Genetic manipulations and the biological future of the human species -- App.1. Methods for estimating gene frequencies -- App.2. Testing and estimating segregation ratios; correction of ascertainment biases in rare diseases; multifactorial and mixed models; related statistical problems -- App.3. Data bases and expert systems -- App.4. Diagnosis of Zygosity -- App.5. Heritability estimates from twin data -- App.6. Genetic counseling -- App.7. Linkage calculations: programs and examples -- App.8. Standardized nomenclature for human genes.

Konu Terimleri:

Added Author:

Motulsky, Arno G., 1923-

Mevcut:*

Library	Materyal Türü	Barkod	Yer Numarası	Durum
Searching... Pamukkale Merkez Kütüphanesi	Kitap	0013411	QH431V59 1997	Searching... Unknown

Bound With These Titles

On Order

Özet

The fourth, completely revised edition of this classical reference and textbook presents a cohesive and up-to-date exposition of the concepts, results, and problems underlying theory and practice in human and medical genetics. In the 10 years since the appearance of the third edition, many new insights have emerged for understanding the genetic basis of development and function in human health and disease. Human genetics, with its emphasis on molecular concepts and techniques, has become a key discipline in medicine and the biomedical sciences.The fourth edition has been extensively expanded by new chapters on hot topics such as epigenetics, pharmacogenetics, gene therapy, cloning and genetic epidemiology. In addition a section giving an overview on the main model organisms (mouse, canine, dog, worm, fly, yeast) used in human genetics research has been introduced. This book will be of interest to human and medical geneticists, scientists in all biomedical sciences, physicians and epidemiologists, as well as to graduate and postgraduate students who desire to learn the fundamentals of this fascinating field.

Author Notes

Arno Gunther Motulsky was born in Fischhausen, Germany on July 5, 1923. In 1939, he was one of more than 900 Jewish refugees aboard the German liner St. Louis who were turned away from Cuba and the United States. Before returning to Germany, four countries agreed to take one-fourth of the passengers. His family was assigned to Belgium. On May 10, 1940, the Germans invaded Belgium. Even though the family had just received United States visas, they were unable to leave. Motulsky was sent to an internment camp in France. In June 1941, he left France and traveled through Spain to Portugal, where he boarded a ship to the United States.

In 1942, he passed the high school equivalency tests in Chicago. He worked and began taking college courses at Central Y.M.C.A. College. In 1943, he had been accepted to medical school at the University of Illinois at Chicago. However, he was drafted and the Army sent him to Yale University to finish his premedical courses. He returned to the University of Illinois for medical school, entering as a private first class. He graduated in 1947 and took further training in internal medicine and hematology. In 1951, he was called back into the Army and assigned to Walter Reed Army Medical Center in Washington, where he studied inherited blood disorders. He was discharged in 1953.

After being discharged, he became an instructor at the University of Washington's new medical school in Seattle. He taught internal medicine and hematology. He was the founder of medical genetics and pharmacogenetics. In 1957, he started one of the first divisions of medical genetics in the United States. He was the author of more than 400 scientific articles. He and Friedrich Vogel wrote the textbook, Human Genetics: Problems and Approaches, in 1979. Motulsky died on January 17, 2018 at the age of 94.

(Bowker Author Biography)