Biochemistry of signal transduction and regulation

Başlık:

Yazar:

Krauss, Gerhard.

ISBN:

9783527305919

Ek Yazar:

Krauss, Gerhard.

Edition:

3rd completely rev. ed.

Yayım Bilgisi:

Weinheim : Wiley-VCH, 2005.

Fiziksel Tanım:

xvi, 541 p. : ill. (some col.) ; 24 cm.

Contents:

The regulation of gene expression -- The regulation of enzyme activity -- Structure and function of signal pathways -- Signaling by nuclear receptors -- G protein-coupled signal transmission pathways -- Intracellular messenger substance : second messengers -- Ser/Thr-specific protein kinases and protein phosphates -- Signal transmission via transmembrane receptors with tyrosine-specific protein kinase activity -- Signal transmission via ras proteins -- Intracellular signal transduction : the protein cascades of the MAP kinase pathways -- Membrane receptors with associated tyrosine kinase activity -- Other receptor classes -- Regulation of the cell cycle -- Malfunction of signaling pathways and tumorigenesis : oncogenes and tumor suppressor genes -- Apoptosis.

Konu Terimleri:

Hücresel sinyal iletimi.

Hücre kontrol mekanizması.

Hücre etkileşimi.

Genetik düzenleme.

Sinyal iletimi.

Cellular signal transduction.

Cellular control mechanisms.

Cell Communication.

Gene Expression Regulation.

Signal Transduction.

Mevcut:*

Library	Materyal Türü	Barkod	Yer Numarası	Durum
Searching... Pamukkale Merkez Kütüphanesi	Kitap	0039686	QH 604.2K73 2005	Searching... Unknown

Bound With These Titles

On Order

Özet

This all-new edition of a classic text has been thoroughly revised to keep pace with the rapid progress in signal transduction research. With didactic skill and clarity, the author relates the observed biological phenomena to the underlying biochemical processes.

Directed at advanced students, teachers, and researchers in biochemistry and molecular biology, this book describes the molecular basis of signal transduction, regulated gene expression, the cell cycle, tumorigenesis and apoptosis.

From the reviews of the previous edition:

"Provides a comprehensive account of cell signaling and signal transduction and, where possible, explains these processes at the molecular level"
- Angewandte Chemie

"The clear and didactic presentation makes it a textbook very useful for students and researchers not familiar with all aspects of cell regulation."
- Biochemistry

"This book is actually two books: Regulation and Signal Transduction."
- Drug Research

Author Notes

Gerhard Krauss is Professor of Biochemistry at the University of Bayreuth (Germany). His resarch is centered on the mechanism of interaction of DNA binding proteins and their target DNA. He is specifically interested in transcription factor, DNA methyl transferases and nucleotide excision repair.
The idea for a textbook on Signal Transduction and Gene Regulation originated from a lecture course that he has been teaching at Bayreuth since the middle of the 1990s.

Preface	p. VI
1 The Regulation of Gene Expression	p. 1
1.1 Regulation of Gene Expression: How and Where? A Schematic Overview	p. 1
1.2 Protein-Nucleic Acid Interactions as a Basis for Specific Gene Regulation	p. 3
1.2.1 Structural Motifs of DNA-binding Proteins	p. 3
1.2.2 The Nature of the Specific Interactions in Protein-Nucleic Acid Complexes	p. 9
1.2.3 The Role of the DNA Conformation in Protein-DNA Interactions	p. 11
1.2.4 Structure of the Recognition Sequence and Quaternary Structure of DNA-binding Proteins	p. 13
1.3 The Principles of Transcription Regulation	p. 17
1.3.1 Elements of Transcription Regulation	p. 17
1.3.2 Functional Requirements for Repressors and Transcriptional Activators	p. 19
1.3.3 Mechanisms for the Control of the Activity of DNA-binding Proteins	p. 20
1.3.3.1 Binding of Effector Molecules	p. 21
1.3.3.2 Binding of Inhibitory Proteins	p. 23
1.3.3.3 Modification of Regulatory Proteins	p. 23
1.3.3.4 Changes in the Concentration of Regulatory DNA-binding Proteins	p. 24
1.4 Regulation of Transcription in Eucaryotes	p. 25
1.4.1 Overview of Transcription Initiation in Procaryotes	p. 26
1.4.2 The Basic Features of Eukaryotic Transcription	p. 28
1.4.3 The Eucaryotic Transcription Apparatus	p. 30
1.4.3.1 Structure of the Transcription Start Site and Regulatory Sequences	p. 30
1.4.3.2 Elementary Steps of Eucaryotic Transcription	p. 32
1.4.3.3 Formation of a Basal Transcription Apparatus from General Transcription Factors and RNA Polymerase	p. 33
1.4.3.4 Phosphorylation of RNA Polymerase II and the Onset of Transcription	p. 36
1.4.3.5 TFIIH--a Pivotal Regulatory Protein Complex	p. 38
1.4.4 Regulation of Eucaryotic Transcription by DNA-binding Proteins	p. 39
1.4.4.1 The Structure of Eucaryotic Transcriptional Activators	p. 39
1.4.4.2 Concerted Action of Transcriptional Activators and Coactivators in the Regulation of Transcription	p. 41
1.4.4.3 Interactions with the Transcription Apparatus	p. 45
1.4.5 Regulation of the Activity of Transcriptional Activators	p. 45
1.4.5.1 The Principal Pathways for the Regulation of Transcriptional Activators	p. 46
1.4.5.2 Phosphorylation of Transcriptional Activators	p. 46
1.4.5.3 Heterotypic Dimerization	p. 50
1.4.5.4 Regulation by Binding of Effector Molecules	p. 52
1.4.6 Specific Repression of Transcription	p. 52
1.4.7 Chromatin Structure and Transcription Activation	p. 55
1.4.7.1 Transcriptional Activity and Histone Acetylation	p. 58
1.4.7.2 Transcriptional Activity and Histone Methylation	p. 62
1.4.7.3 Enhanceosomes	p. 63
1.4.8 Methylation of DNA	p. 65
1.5 Post-transcriptional Regulation of Gene Expression	p. 68
1.5.1 Modifications at the 5' and 3' Ends of the Pre-mRNA	p. 69
1.5.2 Formation of Alternative mRNA by Alternative Polyadenylation and by Alternative Splicing	p. 70
1.5.3 Regulation via Transport and Splicing of Pre-mRNA	p. 73
1.5.4 Stability of the mRNA	p. 75
1.5.5 Regulation at the Level of Translation	p. 78
1.5.5.1 Regulation by binding of protein to the 5' end of the mRNA	p. 79
1.5.5.2 Regulation by Modification of Initiation Factors	p. 80
2 The Regulation of Enzyme Activity	p. 89
2.1 Enzymes as Catalysts	p. 90
2.2 Regulation of Enzymes by Effector Molecules	p. 91
2.3 Principal Features of Allosteric Regulation	p. 93
2.4 Regulation of Enzyme Activity by Binding of Inhibitor and Activator Proteins	p. 94
2.5 Regulation of Enzyme Activity by Phosphorylation	p. 95
2.5.1 Regulation of Glycogen Phosphorylase by Phosphorylation	p. 97
2.5.2 Regulation of Isocitrate Dehydrogenase (E. coli) by Phosphorylation	p. 100
2.6 Regulation via the Ubiquitin-Proteasome Pathway	p. 101
2.6.1 Components of the Ubiquitin System	p. 102
2.6.2 Degradation in the Proteasome	p. 107
2.6.3 Recognition of the Substrate in the Ubiquitin-Proteasome Degradation Pathway	p. 108
2.6.4 Regulatory Function of Ubiquitin Conjugation and the Targeted Degradation of Proteins	p. 110
2.7 Regulation of Proteins by Sumoylation	p. 113
3 Structure and Function of Signal Pathways	p. 115
3.1 General Function of Signal Pathways	p. 115
3.2 Structure of Signaling Pathways	p. 117
3.2.1 The Mechanisms of Intercellular Communication	p. 117
3.2.2 Principles of Intracellular Signal Transduction	p. 119
3.2.3 Components of Intracellular Signal Transduction	p. 120
3.2.4 Coupling of Proteins in Signaling Chains	p. 122
3.2.4.1 Coupling by Specific Protein-Protein Interactions	p. 122
3.2.4.2 Coupling by Protein Modules	p. 122
3.2.4.3 Coupling by Reversible Docking Sites	p. 123
3.2.4.4 Coupling by Colocalization	p. 123
3.2.4.5 Linearity, Branching and Crosstalk	p. 124
3.2.4.6 Variability and Specificity of Receptors and Signal Responses	p. 126
3.3 Extracellular Signaling Molecules	p. 128
3.3.1 The Chemical Nature of Hormones	p. 128
3.3.2 Hormone Analogs: Agonists and Antagonists	p. 131
3.3.3 Endocrine, Paracrine and Autocrine Signaling	p. 133
3.3.4 Direct Modification of Protein by Signaling Molecules	p. 133
3.4 Hormone Receptors	p. 135
3.4.1 Recognition of Hormones by Receptors	p. 135
3.4.2 The Interaction between Hormone and Receptor	p. 135
3.5 Signal Amplification	p. 139
3.6 Regulation of Inter- and Intracellular Signaling	p. 141
3.7 Membrane Anchoring and Signal Transduction	p. 142
3.7.1 Myristoylation	p. 144
3.7.2 Palmitoylation	p. 145
3.7.3 Farnesylation and Geranylation	p. 146
3.7.4 The Glycosyl-Phosphatidyl-Inositol Anchor (GPI Anchor)	p. 147
3.7.5 The Switch Function of Lipid Anchors	p. 148
4 Signaling by Nuclear Receptors	p. 151
4.1 Ligands of Nuclear Receptors	p. 151
4.2 Principles of Signaling by Nuclear Receptors	p. 153
4.3 Classification and Structure of Nuclear Receptors	p. 156
4.3.1 DNA-Binding Elements of Nuclear Receptors, HREs	p. 156
4.3.2 The DNA-Binding Domain of Nuclear Receptors	p. 159
4.3.3 HRE Recognition and Structure of the HRE-Receptor Complex	p. 161
4.3.4 Ligand-binding Domains	p. 162
4.3.5 Transactivating Elements of the Nuclear Receptors	p. 164
4.4 Mechanisms of Transcriptional Regulation by Nuclear Receptors	p. 165
4.5 Regulation and Variability of Signaling by Nuclear Receptors	p. 169
4.6 The Signaling Pathway of the Steroid Hormone Receptors	p. 171
4.7 Signaling by Retinoids, Vitamin D3, and the T3-Hormone	p. 173
4.7.1 Structure of the HREs of RXR Heterodimers	p. 175
4.7.2 Complexity of the Interaction between HRE, Receptor and Hormone	p. 175
5 G Protein-Coupled Signal Transmission Pathways	p. 179
5.1 Transmembrane Receptors: General Structure and Classification	p. 179
5.2 Structural Principles of Transmembrane Receptors	p. 181
5.2.1 The Extracellular Domain of Transmembrane Receptors	p. 181
5.2.2 The Transmembrane Domain	p. 183
5.2.3 The Intracellular Domain of Membrane Receptors	p. 185
5.2.4 Regulation of Receptor Activity	p. 186
5.3 G Protein-Coupled Receptors	p. 187
5.3.1 Structure of G Protein-Coupled Receptors	p. 188
5.3.2 Ligand Binding	p. 191
5.3.3 Mechanism of Signal Transmission	p. 192
5.3.4 Switching Off and Desensitization of 7-Helix Transmembrane Receptors	p. 192
5.3.5 Dimerization of GPCRs	p. 196
5.4 Regulatory GTPases	p. 197
5.4.1 The GTPase Superfamily: General Functions and Mechanism	p. 197
5.4.2 Inhibition of GTPases by GTP Analogs	p. 200
5.4.3 The G-domain as Common Structural Element of the GTPases	p. 200
5.4.4 The Different GTPase Families	p. 201
5.5 The Heterotrimeric G Proteins	p. 202
5.5.1 Classification of the Heterotrimeric G Proteins	p. 203
5.5.2 Toxins as Tools in the Characterization of Heterotrimeric G Proteins	p. 205
5.5.3 The Functional Cycle of Heterotrimeric G Proteins	p. 206
5.5.4 Structural and Mechanistic Aspects of the Switch Function of G Proteins	p. 208
5.5.5 Structure and Function of the [beta gamma]-Complex	p. 215
5.5.6 Membrane Association of the G Proteins	p. 217
5.5.7 Regulators of G Proteins: Phosducin and RGS Proteins	p. 218
5.6 Effector Molecules of G Proteins	p. 220
5.6.1 Adenylyl Cyclase and cAMP as Second Messenger	p. 220
5.6.2 Phospholipase C	p. 225
6 Intracellular Messenger Substances: Second Messengers	p. 231
6.1 General Functions of Intracellular Messenger Substances	p. 231
6.2 cAMP	p. 233
6.3 cGMP	p. 235
6.4 Metabolism of Inositol Phospholipids and Inositol Phosphates	p. 237
6.5 Inositol 1,4,5-Triphosphate and Release of Ca[superscript 2+]	p. 240
6.5.1 Release of Ca[superscript 2+] from Ca[superscript 2+] Storage	p. 241
6.5.2 Influx of Ca[superscript 2+] from the Extracellular Region	p. 245
6.5.3 Removal and Storage of Ca[superscript 2+]	p. 246
6.5.4 Temporal and Spatial Changes in Ca[superscript 2+] Concentration	p. 246
6.6 Phosphatidyl Inositol Phosphates and PI3-Kinase	p. 248
6.6.1 PI3-Kinases	p. 249
6.6.2 The Messenger Substance PtdIns(3,4,5)P[subscript 3]	p. 250
6.6.3 Akt Kinase and PtdIns(3,4,5)P[subscript 3] Signaling	p. 252
6.6.4 Functions of PtIns(4,5)P[subscript 2]	p. 253
6.7 Ca[superscript 2+] as a Signal Molecule	p. 253
6.7.1 Calmodulin as a Ca[superscript 2+] Receptor	p. 256
6.7.2 Target Proteins of Ca[superscript 2+]/Calmodulin	p. 257
6.7.3 Other Ca[superscript 2+] Receptors	p. 258
6.8 Diacylglycerol as a Signal Molecule	p. 259
6.9 Other Lipid Messengers	p. 260
6.10 The NO Signaling Molecule	p. 261
6.10.1 Reactivity and Stability of NO	p. 262
6.10.2 Synthesis of NO	p. 263
6.10.3 Physiological Functions and Attack Points of NO	p. 264
7 Ser/Thr-specific Protein Kinases and Protein Phosphatases	p. 269
7.1 Classification, Structure and Characteristics of Protein Kinases	p. 269
7.1.1 General Classification and Function of Protein Kinases	p. 269
7.1.2 Classification of Ser/Thr-specific Protein Kinases	p. 272
7.2 Structure and Regulation of Protein Kinases	p. 273
7.2.1 Main Structural Elements of Protein Kinases	p. 274
7.2.2 Substrate Binding and Recognition	p. 276
7.2.3 Control of Protein Kinase Activity	p. 277
7.3 Protein Kinase A	p. 280
7.3.1 Structure and Substrate Specificity of Protein Kinase A	p. 280
7.3.2 Regulation of Protein Kinase A	p. 281
7.4 Protein Kinase C	p. 283
7.4.1 Characterization and Classification	p. 283
7.4.2 Structure and Activation of Protein Kinase C	p. 286
7.4.3 Regulation of Protein Kinase C	p. 288
7.4.4 Functions and Substrates of Protein Kinase C	p. 290
7.5 Ca[superscript 2+]/Calmodulin-dependent Protein Kinases	p. 292
7.5.1 Importance and General Function	p. 292
7.5.2 Structure and Autoregulation of CaM Kinase II	p. 293
7.6 Ser/Thr-specific Protein Phosphatases	p. 296
7.6.1 Structure and Classification of Ser/Thr Protein Phosphatases	p. 296
7.6.2 Regulation of Ser/Thr Protein Phosphatases	p. 297
7.6.3 Protein Phosphatase I, PPI	p. 299
7.6.4 Protein Phosphatase 2A, PP2A	p. 301
7.6.5 Protein Phosphatase 2B, Calcineurin	p. 302
7.7 Regulation of Protein Phosphorylation by Subcellular Localization	p. 305
8 Signal Transmission via Transmembrane Receptors with Tyrosine-Specific Protein Kinase Activity	p. 311
8.1 Structure and Function of Receptor Tyrosine Kinases	p. 311
8.1.1 General Structure and Classification	p. 313
8.1.2 Ligand Binding and Activation	p. 314
8.1.3 Structure and Activation of the Tyrosine Kinase Domain	p. 319
8.1.4 Effector Proteins of the Receptor Tyrosine Kinases	p. 323
8.1.5 Attenuation and Termination of RTK Signaling	p. 326
8.2 Protein Modules as Coupling Elements of Signal Proteins	p. 328
8.2.1 SH2 Domains	p. 329
8.2.2 Phosphotyrosine-binding Domain (PTB Domain)	p. 332
8.2.3 SH3 Domains	p. 332
8.2.4 Membrane-targeting Domains: Pleckstrin Homology (PH) Domains and FYVE Domains	p. 334
8.2.5 Phosphoserine/Threonine-binding Domains	p. 335
8.2.6 PDZ Domains	p. 336
8.3 Nonreceptor Tyrosine-specific Protein Kinases	p. 337
8.3.1 Structure and General Function of Nonreceptor Tyrosine Kinases	p. 337
8.3.2 Src Tyrosine Kinase and Abl Tyrosine Kinase	p. 338
8.4 Protein Tyrosine Phosphatases	p. 342
8.4.1 Structure and Classification of Protein Tyrosine Phosphatases	p. 343
8.4.2 Cooperation of Protein Tyrosine Phosphatases and Protein Tyrosine Kinases	p. 346
8.4.3 Regulation of Protein Tyrosine Phosphatases	p. 348
8.5 Adaptor Molecules of Intracellular Signal Transduction	p. 351
9 Signal Transmission via Ras Proteins	p. 355
9.1 The Ras Superfamily of Monomeric GTPases	p. 355
9.2 General Importance of Ras Protein	p. 358
9.3 Structure and Biochemical Properties of Ras Protein	p. 360
9.3.1 Structure of the GTP- and GDP-bound Forms of Ras Protein	p. 361
9.3.2 GTP Hydrolysis: Mechanism and Stimulation by GAP Proteins	p. 363
9.3.3 Structure and Biochemical Properties of Transforming Mutants of Ras Protein	p. 366
9.4 Membrane Localization of Ras Protein	p. 366
9.5 GTPase-activating Protein (GAP) in Ras Signal Transduction	p. 368
9.6 Guanine Nucleotide Exchange Factors (GEFs) in Signal Transduction via Ras Proteins	p. 369
9.6.1 General Function of GEFs	p. 369
9.6.2 Structure and Activation of GEFs	p. 369
9.7 Raf Kinase as an Effector of Signal Transduction by Ras Proteins	p. 373
9.7.1 Structure of Raf Kinase	p. 373
9.7.2 Interaction of Raf Kinase with Ras Protein	p. 374
9.7.3 Mechanism of Activation and Regulation of Raf Kinase	p. 374
9.8 Reception and Transmission of Multiple Signals by Ras Protein	p. 375
10 Intracellular Signal Transduction: the Protein Cascades of the MAP Kinase Pathways	p. 383
10.1 Components of MAPK Pathways	p. 385
10.2 The Major MAPK Pathways of Mammals	p. 388
10.2.1 The ERK Pathway	p. 388
10.2.2 The JNK/SAPK, p38 and ERK5 MAPK Pathways	p. 391
11 Membrane Receptors with Associated Tyrosine Kinase Activity	p. 395
11.1 Cytokines and Cytokine Receptors	p. 395
11.2 Structure and Activation of Cytokine Receptors	p. 396
11.2.1 Activation of Cytoplasmic Tyrosine Kinases	p. 401
11.2.2 The Jak-Stat Pathway	p. 405
11.2.2.1 The Janus Kinases	p. 405
11.2.2.2 The Stat Proteins	p. 406
11.3 T and B Cell Antigen Receptors	p. 409
11.3.1 Receptor Structure	p. 410
11.3.2 Intracellular Signal Molecules of the T and B Cell Antigen Receptors	p. 411
11.4 Signal Transduction via Integrins	p. 413
12 Other Receptor Classes	p. 417
12.1 Receptors with Intrinsic Ser/Thr Kinase Activity: the TGF[beta] Receptor and the Smad Proteins	p. 417
12.1.1 TGF[beta] Receptor	p. 417
12.1.2 Smad Proteins	p. 418
12.2 Receptor Regulation by Intramembrane Proteolysis	p. 422
12.3 Signal Transduction via the Two-Component Pathway	p. 424
13 Regulation of the Cell Cycle	p. 429
13.1 Overview of the Cell Cycle	p. 429
13.1.1 Principles of Cell Cycle Control	p. 429
13.1.2 Intrinsic Control Mechanisms	p. 431
13.1.3 External Control Mechanisms	p. 433
13.1.4 Critical Cell Cycle Events and Cell Cycle Transitions	p. 434
13.2 Key Elements of the Cell Cycle Apparatus	p. 434
13.2.1 Cyclin-dependent Protein Kinases, CDKs	p. 435
13.2.2 Structure of CDKs and Regulation by Phosphorylation	p. 437
13.2.3 Cyclins	p. 439
13.2.4 Regulation of Cyclin Concentration	p. 440
13.2.5 Structural Basis for CDK Activation	p. 442
13.2.6 Inhibitors of CDKs: the CKIs	p. 445
13.2.7 Substrates of CDKs	p. 447
13.2.8 Multiple Regulation of CDKs	p. 449
13.3 Regulation of the Cell Cycle by Proteolysis	p. 449
13.3.1 Targeted Proteolysis by the SCF Complex	p. 451
13.3.2 Proteolysis during Mitosis: the Anaphase-promoting Complex/Cyclosome	p. 452
13.4 The G[subscript 1]/S Phase Transition	p. 453
13.4.1 Function of the D-type Cyclins	p. 454
13.4.2 Function of pRb in the Cell Cycle	p. 456
13.5 Cell Cycle Control of DNA Replication	p. 461
13.6 The G[subscript 2]/M Transition and Cdc25 Phosphatase	p. 463
13.7 Summary of Cell Cycle Progression	p. 465
13.8 The DNA Damage Checkpoints	p. 466
14 Malfunction of Signaling Pathways and Tumorigenesis: Oncogenes and Tumor Suppressor Genes	p. 469
14.1 General Aspects of Tumor Formation	p. 469
14.1.1 Characteristics of Tumor Cells	p. 469
14.1.2 Genetic Changes in Tumor Cells	p. 471
14.1.3 Epigenetic Changes in Tumor Cells	p. 472
14.1.4 Causes of Oncogenic Mutations	p. 473
14.1.5 DNA Repair, DNA Damage Checkpoints, and Tumor Formation	p. 474
14.1.6 Cell Division and Tumor Formation	p. 475
14.2 Cell Division Activity, Errors in Function of Signal Proteins, and Tumor Formation	p. 475
14.2.1 The Fate of a Cell: Quiescence, Division, or Death	p. 476
14.3 Definition and General Function of Oncogenes and Tumor Suppressor Genes	p. 477
14.3.1 Oncogenes and Proto-Oncogenes	p. 478
14.3.2 Mechanisms of Activation of Proto-Oncogenes	p. 479
14.3.3 Examples of the Functions of Oncogenes	p. 482
14.4 Tumor Suppressor Genes: General Functions	p. 487
14.5 DNA Repair, DNA Integrity and Tumor Suppression	p. 488
14.6 The Retinoblastoma Protein pRb in Cancer	p. 490
14.7 The p16[superscript INK4a] Gene Locus and ARF	p. 493
14.8 The Tumor Suppressor Protein p53	p. 494
14.8.1 Structure and Biochemical Properties of the p53 Protein	p. 495
14.8.2 Sequence-Specific DNA Binding of p53	p. 496
14.8.3 Genes Regulated by p53	p. 498
14.8.4 Activation, Regulation and Modulation of the Function of p53	p. 500
14.8.5 Overview of p53 Regulation	p. 502
14.8.6 The MDM2-p53 Network and Cancer	p. 505
14.9 The Tumor Suppressor APC and Wnt/[beta]-Catenin Signaling	p. 507
15 Apoptosis	p. 511
15.1 Basic Functions of Apoptosis	p. 511
15.2 Overview of Apoptosis	p. 513
15.3 Caspases: Death by Proteolysis	p. 515
15.4 The Family of Bcl-2 Proteins: Gatekeepers of Apoptosis	p. 520
15.5 The Mitochondrial Pathway of Apoptosis	p. 522
15.6 Death Receptor-triggered Apoptosis	p. 524
15.6.1 The Fas/CD95 Signaling Pathway	p. 525
15.6.2 Tumor Necrosis Factor-Receptor 1 and Apoptosis	p. 527
15.7 Links of Apoptosis and Cellular Signaling Pathways	p. 528
15.7.1 P13-Kinase/Akt Kinase and Apoptosis	p. 529
15.7.2 The Protein p53 and Apoptosis	p. 530
Index	p. 533

Mevcut:*

Bound With These Titles

On Order

Özet

Özet

Author Notes

Table of Contents